Departamento de Fisiopatología

HOSPITAL DE CLÍNICAS "Dr. Manuel Quintela" - FACULTAD DE MEDICINA - UNIVERSIDAD DE LA REPÚBLICA

Publicaciones


Publicaciones en Revistas Arbitradas por Año

 

2015

Effects of early hemodynamic resuscitation on left ventricular performance and microcirculatory
function during endotoxic shock.
Alejandra López, Juan Carlos Grignola, Martín Angulo, Ignacio Alvez, Nicolás Nin, Gonzalo Lacuesta, Manuel Baz, Pablo Cardinal, Ivana Prestes, Juan P Bouchacourt, Juan Riva, Can Ince and Francisco Javier Hurtado.
Intensive Care Medicine Experimental (2015) 3:14; DOI 10.1186/s40635-015-0049-y.

Inter-rater reliability and diagnostic performance of subjective evaluation of sublingual microcirculation images by physicians and nurses: A multicenter observational study.
Lima A, López A, van Genderen ME, Hurtado J, Angulo M, Grignola J, Shono A, van Bommel J.
Shock (2015) 44:239-44. doi: 10.1097/SHK.0000000000000401.

International study on microcirculatory shock occurrence in acutely ill patients.

Vellinga NA, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Machado FR, Fries M, Akarsu-Ayazoglu T, Pranskunas A, Hollenberg S, Balestra G, van Iterson M, van der Voort PH, Sadaka F, Minto G, Aypar U, Hurtado FJ, Martinelli G, Payen D, van Haren F, Holley A, Pattnaik R, Gomez H, Mehta RL, Rodriguez AH, Ruiz C, Canales HS, Duranteau J, Spronk PE, Jhanji S, Hubble S, Chierego M, Jung C, Martin D, Sorbara C, Tijssen JG, Bakker J, Ince C; microSOAP Study Group.

Crit Care Med. 2015 Jan;43(1):48-56. doi: 10.1097/CCM.0000000000000553.

The emerging role of contractile and vascular reserve in pulmonary arterial hypertension
Grignola JC, Domingo E.
Eur Respir J (2015) 45(6): 1756-58. doi: 10.1183/09031936.00023015

High CO2 Levels Cause Skeletal Muscle Atrophy via AMP-activated Kinase (AMPK), FoxO3a Protein, and Muscle-specific Ring Finger Protein 1 (MuRF1).
Jaitovich A, Angulo M, Lecuona E, Dada LA, Welch LC, Cheng Y, Gusarova G, Ceco E, Liu C, Shigemura M, Barreiro E, Patterson C, Nader GA, Sznajder JI.
J Biol Chem. 2015 Apr 3;290(14):9183-94.

The distribution of the obstruction in the pulmonary arteries modifies pulsatile right ventricular afterload in pulmonary hypertension.
Ruiz-Cano MJ, Grignola JC, Barbera JA, García García S, Lázaro Salvador M, Escribano P on behalf of the REHAP investigators.
Int J Cardiol (2015) 181:232-34.doi: 10.1016/j.ijcard.2014.11.118

Model-free methods to study membrane environmental probes: a comparison of the spectral phasor and generalized polarization approaches.

Malacrida L, Gratton E, Jameson DM.

Methods Appl Fluoresc. 2015 Dec;3(4). pii: 047001

Model-free methods to study membrane environmental probes: a comparison of the spectral phasor and generalized polarization approaches.

Malacrida L, Gratton E, Jameson DM.

Methods Appl Fluoresc. 2015 Nov 12;3(4):047001. doi: 10.1088/2050-6120/3/4/047001.

 

2014

Up-front combination therapy in pulmonary arterial hypertension: from clinical trials to 'real world' observational studies".
Grignola JC.
Int J Cardiol 2014; 173(3): 349-50. doi:10.1016/j.ijcard.2014.03.095

The time constant of the pulmonary circulation, is truly constant?
Grignola JC.
Eur Resp J (2014) 43(5): 1539-41. doi: 10.1183/09031936.00158113

Impairment of pulmonary vascular reserve and right ventricular systolic reserve in pulmonary hypertension.
Domingo E, Grignola JC, Aguilar R, Arredondo Ch, Bouteldja N, López Messeguer M, Roman A.
BMC Pulm Med (2014) 14: 69. doi: 10.1186/1471-2466-14-69

Sevoflurane anesthesia deteriorates pulmonary surfactant promoting alveolar collapse in male Sprague-Dawley rats.
Malacrida L, Reta G, Piriz H, Rocchiccioli F, Botti H, Denicola A,
Briva A.
Pulm Pharmacol Ther. (2014) Jan 3.
pii: S1094-5539(13)00200-9. doi: 10.1016/j.pupt.2013.12.005.


2013

Estenssoro E, Valente Barbas CS, Briva A.
Picking up the pieces: towards a better future for critical care medicine in three South American countries.
Am J Respir Crit Care Med
. 2013 Jan 15;187(2):130-2.

Domingo E, Grignola JC, Aguilar R, Montero MA, Arredondo C, Vázquez M, López-Messeguer M, Bravo C, Bouteldja N, Hidalgo C, Roman A.
In vivo assessment of pulmonary arterial wall fibrosis by intravascular optical coherence tomography in pulmonary arterial hypertension: a new prognostic marker of adverse clinical follow-up.
Open Respir Med J. 2013 Apr 5;7:26-32.

Grignola JC, Domingo E.
Pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension: How can patients be better selected?
World J Cardiol
. 2013 Mar 26;5(3):18-21.

Gadola L, Poggi C, Poggio M, Sáez L, Ferrari A, Romero J, Fumero S, Ghelfi G, Chifflet L, Borges PL.
Using a multidisciplinary training program to reduce peritonitis in peritoneal dialysis patients.
Perit Dial Int
. 2013 Jan-Feb;33(1):38-45.
Franklin SS, Thijs L, Li Y, Hansen TW, Boggia J, Liu Y, Asayama K, Björklund-Bodegård K, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Sandoya E, Kawecka-Jaszcz K, Filipovsky J, Imai Y, Wang J, Ibsen H, O'Brien E, Staessen JA; International Database on Ambulatory blood pressure in Relation to Cardiovascular Outcomes Investigators.
Masked hypertension in diabetes mellitus: treatment implications for clinical practice.
Hypertension. 2013 May;61(5):964-71.


Schutte R, Thijs L, Asayama K, Boggia J, Li Y, Hansen TW, Liu YP, Kikuya M, Björklund-Bodegård K, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Sandoya E, Kawecka-Jaszcz K, Filipovsky J, Imai Y, Wang J, Ibsen H, O'Brien E, Staessen JA; International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes (IDACO) Investigators.
Double product reflects the predictive power of systolic pressure in the general population: evidence from 9,937 participants.
Am J Hypertens. 2013 May;26(5):665-72.


Peñuelas O, Melo E, Sánchez C, Sánchez I, Quinn K, Ferruelo A, Pérez-Vizcaíno F, Esteban A, Navajas D, Nin N, Lorente JA, Farré R.
Antioxidant effect of human adult adipose-derived stromal stem cells in alveolar epithelial cells undergoing stretch.
Respir Physiol Neurobiol
. 2013 Aug 1;188(1):1-8.


Kiehntopf M, Nin N, Bauer M.
Metabolism, metabolome, and metabolomics in intensive care: is it time to move beyond monitoring of glucose and lactate?
Am J Respir Crit Care Med
. 2013 May 1;187(9):906-7.

 

Esteban A, Frutos-Vivar F, Muriel A, Ferguson ND, Peñuelas O, Abraira V, Raymondos K, Rios F, Nin N, Apezteguía C, Violi DA, Thille AW, Brochard L, González M, Villagomez AJ, Hurtado J, Davies AR, Du B, Maggiore SM, Pelosi P, Soto L, Tomicic V, D'Empaire G, Matamis D, Abroug F, Moreno RP, Soares MA, Arabi Y, Sandi F, Jibaja M, Amin P, Koh Y, Kuiper MA, Bülow HH, Zeggwagh AA, Anzueto A.
Evolution of Mortality over Time in Patients Receiving Mechanical Ventilation.
Am J Respir Crit Care Med
. 2013 Jul 15;188(2):220-30. doi: 10.1164/rccm.201212-2169OC.


Algaba A, Nin N; por el GT-IRA de la SEMICYUC.
Alveolar recruitment maneuvers in respiratory distress syndrome.

Med Intensiva
. 2013 June - July;37(5):355-362.


Menendez C, Martinez-Caro L, Moreno L, Nin N, Moral-Sanz J, Morales D, Cogolludo A, Esteban A, Lorente JA, Perez-Vizcaino F.
Pulmonary vascular dysfunction induced by high tidal volume mechanical ventilation*.
Crit Care Med
. 2013 Aug;41(8):e149-55.


Cardinal-Fernández P, Ferruelo A, El-Assar M, Santiago C, Gómez-Gallego F, Martín-Pellicer A, Frutos-Vivar F, Peñuelas O, Nin N, Esteban A, Lorente JA.
Genetic predisposition to acute kidney injury induced by severe sepsis.
J Crit Care. 2013 Aug;28(4):365-70.

Cardinal-Fernández P, Ferruelo A, El-Assar M, Santiago C, Gómez-Gallego F, Martín-Pellicer A, Frutos-Vivar F, Peñuelas O, Nin N, Esteban A, Lorente JA.
Genetic predisposition to acute respiratory distress syndrome in patients with severe sepsis.
Shock. 2013 Mar;39(3):255-60.


Martín-Loeches I, Bermejo-Martin JF, Vallés J, Granada R, Vidaur L, Vergara-Serrano JC, Martín M, Figueira JC, Sirvent JM, Blanquer J, Suarez D, Artigas A, Torres A, Diaz E, Rodriguez A; SEMICYUC/REIPI/CIBERES H1N1 Working Group.
Macrolide-based regimens in absence of bacterial co-infection in critically ill H1N1 patients with primary viral pneumonia.
Intensive Care Med. 2013 Apr;39(4):693-702.


Añón JM, Nin N.
Introduction to the series: "Update": Mechanical ventilation.

Med Intensiva
. 2013 May;37(4):290-291

I

2012

 

Ruiz-Cano MJ, Grignola JC, Cortina J, Jimenez C, Velazquez MT, Gomez-Sanchez MA, Delgado J, Escribano P.
Composite hemodynamic method of pulsatile and steady right ventricular afterload predicts early outcome after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension.

Int J Cardiol
. 2012 Jul 26;158(3):475-6.


Nin M, Cordero R, Doufrechou L, Larre-Borges A, Coria V, Acosta N, Gadola L, Orihuela S, González F, Noboa O.
Post-transplant Henoch-Schonlein purpura de novo: clinical-histological discordance.
Nefrologia
. 2012;32(6):850-2.


Cabalgante MJ, Gadola L, Luzardo L, Márquez M, Boggia J
, Boim MA.
Calcium citrate improves the epithelial-to-mesenchymal transition induced by acidosis in proximal tubular cells. J Bras Nefrol. 2012 Oct-Dec;34(4):343-8.


Boggia J
, Thijs L, Li Y, Hansen TW, Kikuya M, Björklund-Bodegård K, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Schwedt E, Sandoya E, Kawecka-Jaszcz K, Filipovsky J, Imai Y, Wang J, Ibsen H, O'Brien E, Staessen JA; on behalf of the International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes (IDACO) Investigators.
Risk Stratification by 24-Hour Ambulatory Blood Pressure and Estimated Glomerular Filtration Rate in 5322 Subjects From 11 Populations.
Hypertension
. 2012 Nov 19. [Epub ahead of print]


Vadász I, Dada LA, Briva A, Helenius IT, Sharabi K, Welch LC, Kelly AM, Grzesik BA, Budinger GR, Liu J, Seeger W, Beitel GJ, Gruenbaum Y, Sznajder JI.
Evolutionary Conserved Role of c-Jun-N-Terminal Kinase in CO(2)-Induced Epithelial Dysfunction.
PLoS One
. 2012;7(10):e46696. doi: 10.1371/journal.pone.0046696. Epub 2012 Oct 8.

 

Seija M, Baccino C, Nin N, Sánchez-Rodríguez C, Granados R, Ferruelo A, Martínez-Caro L, Ruíz-Cabello J, de Paula M, Noboa O, Esteban A, Lorente JA.
Role of Peroxynitrite in Sepsis- Induced Acute Kidney Injury in an Experimental Model of Sepsis in Rats.

Shock
. 2012 Jul 6. [Epub ahead of print]

 

Angulo M, Lecuona E, Sznajder JI.
Role of MicroRNAs in Lung Disease.

Arch Bronconeumol
. 2012 May 16. [Epub ahead of print] English, Spanish.

Luzardo L, Lujambio I, Sottolano M, da Rosa A
, Thijs L, Noboa O, Staessen JA, Boggia J.
24-h ambulatory recording of aortic pulse wave velocity and central systolic augmentation: a feasibility study.
Hypertens Res. 2012 May 24. doi: 10.1038/hr.2012.78. [Epub ahead of print]


Rego N, Bianchi S, Moreno P, Persson H, Kvist A, Pena A, Oppezzo P, Naya H, Rovira C, Dighiero G, Pritsch O.
Search for an aetiological virus candidate in chronic lymphocytic leukaemia by extensive transcriptome analysis.
Br J Haematol. 2012 Apr 10. doi: 10.1111/j.1365-2141.2012.09116.x. [Epub ahead of print]


Melania Kurdián
, Inmaculada Herrero-Fresneda, Nuria Lloberas, Pepita Gimenez-Bonafe, Virginia
Coria, María T. Grande, José Boggia, Leonel Malacrida, Joan Torras, Miguel A. Arévalo, Francisco
González-Martínez, José M. López-Novoa, Josep Grinyó, Oscar Noboa.
Delayed mTOR Inhibition with Low Dose of Everolimus Reduces TGFb Expression, Attenuates Proteinuria and Renal Damage in the Renal Mass Reduction Model
PLoS ONE 7(3): e32516. doi:10.1371/journal.pone.0032516

Sergio Bianchi, Guillermo Dighiero and Otto Pritsch.
Selected Topics in Chronic Lymphocytic Leukemia Pathogenesis.
Chronic Lymphocytic Leukemia, chapter 1, pp3-18 (2012). Ed.: Pablo Oppezzo. InTech publisher, ISBN: 978-953-307-881-6.

 

2011

 

Assessment of structural and functional pulmonary vascular disease in patients with pulmonary hypertension.
Grignola JC, Domingo E, Aguilar R, Roman A.
Pulmonary Hypertension - From Bench Research to Clinical Challenges. Chapter 8, pp169-190. Eds: Sulica R & Preston I. Intech open acces Publisher. ISBN 978-953-307-835-9.

Assessment of right ventricular afterload by pressure waveform analysis in acute pulmonary hypertension
Juan C Grignola, Enric Domingo, Lucía Devera, Fernando Ginés
World J Cardiol 2011 October 26; 3(10): 322-328

A metabolomic approach for diagnosis of experimental sepsis.
Izquierdo-García JL, Nin N, Ruíz-Cabello J, Rojas Y, de Paula M, López-Cuenca S, Morales L, Martínez-Caro L, Fernández-Segoviano P, Esteban A, Lorente JA.
Intensive Care Med
. 2011 Oct 6.

White-coat Hypertension on Automated Blood Pressure Measurement: Implications for Clinical Practice
José Boggia, Tine W.Hansen, Kei Asayama, Leonella Luzardo, Yan Li and Jan A. Staessen.
Eur. J.of Cardiovasc. Med. 2011 Aug 1 (4): 17-21 Review

Adenosine triphosphate-dependent calcium signaling during ventilator-induced lung injury is amplified by hypercapnia.
Briva A, Santos C, Malacrida L, Rocchiccioli F, Soto J, Angulo M, Batthyany C, Cairoli E, Piriz H.
Exp Lung Res
. 2011 Oct;37(8):471-81.

Acute absolute vasodilatation is associated with a lower vascular wall stiffness in pulmonary arterial hypertension.
Grignola JC
, Domingo E, Aguilar R, Vázquez M, López-Messeguer M, Bravo C, Roman A.
Int J Cardiol
. 2011 Jul 23.

Hemodynamic assessment of pulmonary hypertension.
World J Cardiol
. 2011 Jan 26;3(1):10-7.
Grignola JC
.
An Assessment of the Acute Kidney Injury Network Creatinine-Based Criteria in Patients Submitted to Mechanical Ventilation.
Lombardi R, Nin N, Lorente JA, Frutos-Vivar F, Ferguson ND, Hurtado J, Apezteguia C, Desmery P, Raymondos K, Tomicic V, Cakar N, González M, Elizalde J, Nightingale P, Abroug F, Jibaja M, Arabi Y, Moreno R, Matamis D, Anzueto A, Esteban A; for the VENTILA Group.
Clin J Am Soc Nephrol
. 2011 Jul;6(7):1547-1555. Epub 2011 Jun 23.

Characteristics and Outcomes of Ventilated Patients According to Time to Liberation from Mechanical Ventilation.
Peñuelas O, Frutos-Vivar F, Fernández C, Anzueto A, Epstein SK, Apezteguía C, González M, Nin N, Raymondos K, Tomicic V, Desmery P, Arabi Y, Pelosi P, Kuiper M, Jibaja M, Matamis D, Ferguson ND, Esteban A; for the Ventila Group.
Am J Respir Crit Care Med
. 2011 May 26. [Epub ahead of print]

Vascular Dysfunction in Sepsis: Effects of the Peroxynitrite Decomposition Catalyst MnTMPyP.
Nin N
, El-Assar M, Sánchez C, Ferruelo A, Sánchez-Ferrer A, Martínez-Caro L, Rojas Y, Paula M, Hurtado J, Esteban A, Lorente JA.
Shock
. 2011 Aug;36(2):156-61.

Kidney histopathological findings in fatal pandemic 2009 influenza A (H1N1).
Nin N, Lorente JA, Sánchez-Rodríguez C, Granados R, Ver LS, Soto L, Hidalgo J, Fernández-Segoviano P, Ortín J, Esteban A.
Intensive Care Med
. 2011 May;37(5):880-1. Epub 2011 Mar 11.

Management and outcome of mechanically ventilated neurologic patients.
Pelosi P, Ferguson ND, Frutos-Vivar F, Anzueto A, Putensen C, Raymondos K, Apezteguia C, Desmery P, Hurtado J, Abroug F, Elizalde J, Tomicic V, Cakar N, Gonzalez M, Arabi Y, Moreno R, Esteban A; Ventila Study Group.
Crit Care Med
. 2011 Jun;39(6):1482-92.

Transcriptional profiling and genotyping of degraded nucleic acids from autopsy tissue samples after prolonged formalin fixation times.
Ferruelo A, El-Assar M, Lorente JA, Nin N, Peñuelas O, Fernández-Segoviano P, Gonzalez C, Esteban A.Int J Clin Exp Pathol. 2011 Jan 6;4(2):156-61.

Clinical characteristics and outcomes of patients with 2009 influenza A(H1N1) virus infection with respiratory failure requiring mechanical ventilation.
Nin N, Soto L, Hurtado J, Lorente JA, Buroni M, Arancibia F, Ugarte S, Bagnulo H, Cardinal P, Bugedo G, Echevarría E, Deicas A, Ortega C, Frutos-Vivar F, Esteban A.
J Crit Care
. 2011 Apr;26(2):186-92.

Hypoxia leads to Na,K-ATPase down-regulation via Ca2+ release-activated Ca2+ (CRAC) channels and AMPK activation.
Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Mutlu GM, Chandel NS, Prakriya M, Sznajder JI.
Mol Cell Biol
. 2011 Jul 5.

Ambulatory Monitoring in Women and Men: It Is Blood Pressure That Matters, Not Heart Rate.
Boggia J
, Hansen TW, Li Y, Kikuya M, Thijs L, Staessen JA.
Hypertension
. 2011 Apr 25.

Are blood pressure and diabetes additive or synergistic risk factors? Outcome in 8494 subjects randomly recruited from 10 populations.
Sehestedt T, Hansen TW, Li Y, Richart T, Boggia J, Kikuya M, Thijs L, Stolarz-Skrzypek K, Casiglia E, Tikhonoff V, Malyutina S, Nikitin Y, Björklund-Bodegård K, Kuznetsova T, Ohkubo T, Lind L, Torp-Pedersen C, Jeppesen J, Ibsen H, Imai Y, Wang J, Sandoya E, Kawecka-Jaszcz K, Staessen JA.
Hypertens Res
. 2011 Jun;34(6):714-21.

Ambulatory blood pressure monitoring in 9357 subjects from 11 populations highlights missed opportunities for cardiovascular prevention in women.
Boggia J
, Thijs L, Hansen TW, Li Y, Kikuya M, Björklund-Bodegård K, Richart T, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Olszanecka A, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Maestre G, Sandoya E, Kawecka-Jaszcz K, Imai Y, Wang J, Ibsen H, O'Brien E, Staessen JA; International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes Investigators.
Hypertension
. 2011 Mar;57(3):397-405.

Predictive role of the nighttime blood pressure.
Hansen TW, Li Y, Boggia J, Thijs L, Richart T, Staessen JA.
Hypertension
. 2011 Jan;57(1):3-10.

 

2010

Airway pressure release ventilation versus assist-control ventilation: a comparative propensity score and international cohort study.
González M, Arroliga AC, Frutos-Vivar F, Raymondos K, Esteban A, Putensen C, Apezteguía C, Hurtado J, Desmery P, Tomicic V, Elizalde J, Abroug F, Arabi Y, Moreno R, Anzueto A, Ferguson ND.
Intensive Care Med
. 2010 May;36(5):817-27.

Early and small changes in serum creatinine concentrations are associated with mortality in mechanically ventilated patients.
Nin N, Lombardi R, Frutos-Vivar F, Esteban A, Lorente JA, Ferguson ND, Hurtado J, Apezteguia C, Brochard L, Schortgen F, Raymondos K, Tomicic V, Soto L, González M, Nightingale P, Abroug F, Pelosi P, Arabi Y, Moreno R, Anzueto A; VENTILA Group.
Shock
. 2010 Aug;34(2):109-16.

Fluidizing effects of C-reactive protein on lung surfactant membranes: protective role of surfactant protein A.
Sáenz A, López-Sánchez A, Mojica-Lázaro J, Martínez-Caro L, Nin N, Bagatolli LA, Casals C.
FASEB J
. 2010 Oct;24(10):3662-73.

Early and small changes in serum creatinine concentration are associated to mortality in mechanically ventilated patients.
Nin N
, Lombardi R, Frutos-Vivar F, Esteba A, Lorente JA, Ferguson ND, Hurtado J, Apezteguia C, Brochard L, Schortgen F, Raymondos K, Tomicic V, Soto L, González M, Nightingale P, Abroug F, Pelosi P, Arabi Y, Moreno R, Anzueto A; for the VENTILA Group..
Shock
. 2010 Feb 10.

Redox balance and cellular inflammation in the diaphragm, limb muscles, and lungs of mechanically ventilated rats.
Marín-Corral J, Martínez-Caro L, Lorente JA, de Paula M, Pijuan L, Nin N, Gea J, Andrés E, Barreiro E.
Anesthesiology
. 2010 Feb;112(2):384-94.

García-Septien J, Lorente JA, Delgado MA, de Paula M, Nin N, Moscoso A, Sánchez-Ferrer A, Perez-Vizcaino F, Esteban A.
Shock
. 2010 Sep;34(3):275-80.

Extracellular signal-regulated kinase (ERK) participates in the hypercapnia-induced Na,K-ATPase downregulation.
Welch LC, Lecuona E, Briva A, Trejo HE, Dada LA, Sznajder JI.
FEBS Lett
. 2010 Sep 24;584(18):3985-9.

Insulin regulates alveolar epithelial function by inducing Na+/K+-ATPase translocation to the plasma membrane in a process mediated by the action of Akt.
Comellas AP, Kelly AM, Trejo HE, Briva A, Lee J, Sznajder JI, Dada LA.
J Cell Sci
. 2010 Apr 15;123(Pt 8):1343-51.

[Permissive and non-permissive hypercapnia: mechanisms of action and consequences of high carbon dioxide levels].
Briva A
, Lecuona E, Sznajder JI.
Arch Bronconeumol
. 2010 Jul;46(7):378-82.

Fatal acute pancreatitis complicated by pancreatic pseudocysts in a patient with systemic lupus erythematosus.
Cairoli E, Pérez G, Briva A, Cancela M, Alonso J.
Rheumatol Int
. 2010 Mar;30(5):675-8.

Blood pressure variability in relation to outcome in the International Database of Ambulatory blood pressure in relation to Cardiovascular Outcome.
Stolarz-Skrzypek K, Thijs L, Richart T, Li Y, Hansen TW, Boggia J, Kuznetsova T, Kikuya M, Kawecka-Jaszcz K, Staessen JA.
Hypertens Res
. 2010 Aug;33(8):757-66.

Prognostic value of isolated nocturnal hypertension on ambulatory measurement in 8711 individuals from 10 populations.
Fan HQ, Li Y, Thijs L, Hansen TW, Boggia J, Kikuya M, Björklund-Bodegård K, Richart T, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Sandoya E, Kawecka-Jaszcz K, Imai Y, Ibsen H, O'Brien E, Wang J, Staessen JA; International Database on Ambulatory Blood Pressure In Relation to Cardiovascular Outcomes Investigators.
J Hypertens
. 2010 Oct;28(10):2036-45.

Stolarz-Skrzypek K, Thijs L, Wizner B, Richart T, Ogedegbe G, Li Y, Hansen TW, Boggia J, Kikuya M, Kuznetsova T, Wang J, Lurbe E, Imai Y, Kawecka-Jaszcz K, Staessen JA.
Blood Press Monit
. 2010 Apr;15(2):72-81.

Li Y, Thijs L, Hansen TW, Kikuya M, Boggia J, Richart T, Metoki H, Ohkubo T, Torp-Pedersen C, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Sandoya E, Kawecka-Jaszcz K, Ibsen H, Imai Y, Wang J, Staessen JA; International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outcomes Investigators.
Hypertension
. 2010 Apr;55(4):1040-8.

Prognostic value of reading-to-reading blood pressure variability over 24 hours in 8938 subjects from 11 populations.
Hansen TW, Thijs L, Li Y, Boggia J, Kikuya M, Björklund-Bodegård K, Richart T, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Sandoya E, Kawecka-Jaszcz K, Imai Y, Wang J, Ibsen H, O'Brien E, Staessen JA; International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes Investigators.
Hypertension
. 2010 Apr;55(4):1049-57.

Immunoglobulin heavy chain V-D-J gene rearrangement and mutational status in Uruguayan patients with chronic lymphocytic leukemia.
Bianchi S
, Moreno P, Landoni AI, Naya H, Oppezzo P, Dighiero G, Gabús R, Pritsch O.
Leuk Lymphoma
. 2010 Nov;51(11):2070-8.

Phylogenetic analysis of bovine leukemia viruses isolated in South America reveals diversification in seven distinct genotypes.
Moratorio G, Obal G, Dubra A, Correa A, Bianchi S, Buschiazzo A, Cristina J, Pritsch O.
Arch Virol
. 2010 Apr;155(4):481-9

 

2009

[Prone position for the treatment of acute respiratory distress syndrome: a review of current literature].
Martínez O, Nin N, Esteban A.
Arch Bronconeumol
. 2009 Jun;45(6):291-6.

[Salbutamol improves diaphragmatic contractility in chronic airway obstruction].
Angulo M, Taranto E, Soto JP, Malacrida L, Nin N, Hurtado FJ, Píriz H
.
Arch Bronconeumol
. 2009 May;45(5):230-4.

Role of free radicals in vascular dysfunction induced by high tidal volume ventilation.
Martínez-Caro L, Lorente JA, Marín-Corral J, Sánchez-Rodríguez C, Sánchez-Ferrer A, Nin N, Ferruelo A, de Paula M, Fernández-Segoviano P, Barreiro E, Esteban A.
Intensive Care Med
. 2009 Jun;35(6):1110-9.

High-tidal volume ventilation aggravates sepsis-induced multiorgan dysfunction in a dexamethasone-inhibitable manner.
Nin N, Lorente JA, Fernández-Segoviano P, De Paula M, Ferruelo A, Esteban A.
Shock
. 2009 Apr;31(4):429-34.

Role of endothelin-1 in acute lung injury.
Comellas AP, Briva A.
Transl Res
. 2009 Jun;153(6):263-71.

Endothelin-1 impairs alveolar epithelial function via endothelial ETB receptor.
Comellas AP, Briva A, Dada LA, Butti ML, Trejo HE, Yshii C, Azzam ZS, Litvan J, Chen J, Lecuona E, Pesce LM, Yanagisawa M, Sznajder JI.
Am J Respir Crit Care Med
. 2009 Jan 15;179(2):113-22.

Use of diaminofluoresceins to detect and measure nitric oxide in low level generating human immune cells.
Tiscornia A, Cairoli E, Marquez M, Denicola A, Pritsch O, Cayota A.
J Immunol Methods
. 2009 Mar 15;342(1-2):49-57.

 

2008

Central venous to mixed venous blood oxygen and lactate gradients are associated with outcome in critically ill patients.
Gutierrez G, Comignani P, Huespe L, Hurtado FJ, Dubin A, Jha V, Arzani Y, Lazzeri S, Sosa L, Riva J, Kohn W, Suarez D, Lacuesta G, Olmos D, Mizdraji C, Ojeda A.
Intensive Care Med
. 2008 Sep;34(9):1662-8.

Rio de La Plata study: a multicenter, cross-sectional study on cardiovascular risk factors and heart failure prevalence in peritoneal dialysis patients in Argentina and Uruguay.
Moretta G, Locatelli AJ, Gadola L, De Arteaga J, Solá L, Caporale N, Schargorodsky J, Ducasse E, Pastorino G, Marchetta N, Espeche W, Ortiz Z.
Kidney Int Suppl
. 2008 Apr;(108):S159-64.

Peritonitis in peritoneal dialysis patients in Uruguay.
Gadola L, Orihuela L, Pérez D, Gómez T, Solá L, Chifflet L, Mautone M, Torres E, Rodriguez G.
Perit Dial Int
. 2008 May-Jun;28(3):232-5.

Rust urine after intense hand drumming is caused by extracorpuscular hemolysis.
Tobal D, Olascoaga A, Moreira G, Kurdián M, Sanchez F, Roselló M, Alallón W, Martinez FG, Noboa O.
Clin J Am Soc Nephrol
. 2008 Jul;3(4):1022-7.

[Salbutamol improves diaphragm force generation in experimental sepsis].
Píriz H, Nin N, Boggia J, Angulo M, Hurtado FJ.

Arch Bronconeumol
. 2008 Mar;44(3):135-9.

Rats surviving injurious mechanical ventilation show reversible pulmonary, vascular and inflammatory changes.
Nin N
, Lorente JA, de Paula M, El Assar M, Vallejo S, Peñuelas O, Fernández-Segoviano P, Ferruelo A, Sánchez-Ferrer A, Esteban A.
Intensive Care Med
. 2008 May;34(5):948-56.

Aging increases the susceptibility to injurious mechanical ventilation.
Nin N
, Lorente JA, De Paula M, Fernández-Segoviano P, Peñuelas O, Sánchez-Ferrer A, Martínez-Caro L, Esteban A.
Intensive Care Med
. 2008 May;34(5):923-31.

Evolution of mechanical ventilation in response to clinical research.
Esteban A, Ferguson ND, Meade MO, Frutos-Vivar F, Apezteguia C, Brochard L, Raymondos K, Nin N, Hurtado J, Tomicic V, González M, Elizalde J, Nightingale P, Abroug F, Pelosi P, Arabi Y, Moreno R, Jibaja M, D'Empaire G, Sandi F, Matamis D, Montañez AM, Anzueto A; VENTILA Group.
Am J Respir Crit Care Med
. 2008 Jan 15;177(2):170-7.

AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis.
Vadász I, Dada LA, Briva A, Trejo HE, Welch LC, Chen J, Tóth PT, Lecuona E, Witters LA, Schumacker PT, Chandel NS, Seeger W, Sznajder JI.
J Clin Invest
. 2008 Feb;118(2):752-62.

Carbonic anhydrase II and alveolar fluid reabsorption during hypercapnia.
Chen J, Lecuona E, Briva A, Welch LC, Sznajder JI.
Am J Respir Cell Mol Biol
. 2008 Jan;38(1):32-7.

Thirty years of research on diagnostic and therapeutic thresholds for the self-measured blood pressure at home.
Staessen JA, Thijs L, Ohkubo T, Kikuya M, Richart T, Boggia J, Adiyaman A, Dechering DG, Kuznetsova T, Thien T, de Leeuw P, Imai Y, O'brien E, Parati G.
Blood Press Monit
. 2008 Dec;13(6):352-65.

Adiyaman A, Dechering DG, Boggia J, Li Y, Hansen TW, Kikuya M, Björklund-Bodegård K, Richart T, Thijs L, Torp-Pedersen C, Ohkubo T, Dolan E, Imai Y, Sandoya E, Ibsen H, Wang J, Lind L, O'Brien E, Thien T, Staessen JA; International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outcomes Investigators.
Hypertension
. 2008 Dec;52(6):1038-44.

Prognostic value of ambulatory heart rate revisited in 6928 subjects from 6 populations.
Hansen TW, Thijs L, Boggia J, Li Y, Kikuya M, Björklund-Bodegård K, Richart T, Ohkubo T, Jeppesen J, Torp-Pedersen C, Lind L, Sandoya E, Imai Y, Wang J, Ibsen H, O'Brien E, Staessen JA; International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes Investigators.
Hypertension
. 2008 Aug;52(2):229-35.

Is blood pressure during the night more predictive of cardiovascular outcome than during the day?
Li Y, Boggia J, Thijs L, Hansen TW, Kikuya M, Björklund-Bodegård K, Richart T, Ohkubo T, Kuznetsova T, Torp-Pedersen C, Lind L, Ibsen H, Imai Y, Wang J, Sandoya E, O'brien E, Staessen JA; International Database on Ambulatory Blood Pressure Monitoring in relation to Cardiovascular Outcomes Investigators.
Blood Press Monit
. 2008 Jun;13(3):145-7.

Putting a spin on the ambulatory arterial stiffness index.
Adiyaman A, Dechering DG, Thien T, Boggia J, Hanssen TW, Li Y, Wang JG, O'Brien E, Staessen JA.
J Hypertens
. 2008 Jun;26(6):1266-7

Diagnostic thresholds for ambulatory blood pressure moving lower: a review based on a meta-analysis-clinical implications.
Hansen TW, Kikuya M, Thijs L, Li Y, Boggia J, Björklund-Bodegârd K, Torp-Pedersen C, Jeppesen J, Ibsen H, Staessen JA.
J Clin Hypertens (Greenwich)
. 2008 May;10(5):377-81. Review.

 

2007

[Physiologic effects of noninvasive ventilation in patients with chronic obstructive pulmonary disease].
Neme JY
, Gutiérrez AM, Santos MC, Berón M, Ekroth C, Arcos JP, Píriz H, Hurtado FJ.
Arch Bronconeumol
. 2007 Mar;43(3):150-5.

Improved right ventricular-vascular coupling during active pulmonary hypertension.
Grignola JC
, Ginés F, Bia D, Armentano R.
Int J Cardiol
. 2007 Feb 7;115(2):171-82.

High CO2 levels impair alveolar epithelial function independently of pH.
Briva A, Vadász I, Lecuona E, Welch LC, Chen J, Dada LA, Trejo HE, Dumasius V, Azzam ZS, Myrianthefs PM, Batlle D, Gruenbaum Y, Sznajder JI.
PLoS One
. 2007 Nov 28;2(11):e1238.

Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study.
Boggia J, Li Y, Thijs L, Hansen TW, Kikuya M, Björklund-Bodegård K, Richart T, Ohkubo T, Kuznetsova T, Torp-Pedersen C, Lind L, Ibsen H, Imai Y, Wang J, Sandoya E, O'Brien E, Staessen JA; International Database on Ambulatory blood pressure monitoring in relation to Cardiovascular Outcomes (IDACO) investigators.
Lancet
. 2007 Oct 6;370(9594):1219-29.

Adiyaman A, Boggia J, Li Y, Wang JG, O'Brien E, Richart T, Thijs L, Staessen JA.
Hypertension
. 2007 Sep;50(3):e59-60

2006

Comparison of the Tei index with invasive measurements of right ventricular function.
Grignola JC
, Ginés F, Guzzo D.
Int J Cardiol
. 2006 Oct 26;113(1):25-33.

Beta-adrenergic receptor stimulation and adenoviral overexpression of superoxide dismutase prevent the hypoxia-mediated decrease in Na,K-ATPase and alveolar fluid reabsorption.
Litvan J, Briva A, Wilson MS, Budinger GR, Sznajder JI, Ridge KM.
J Biol Chem
. 2006 Jul 21;281(29):19892-8.

The role of bundles in sepsis care.
Hurtado FJ, Nin N.
Crit Care Clin
. 2006 Jul;22(3):521-9, x. Review.

Ventilation-induced lung injury in rats is associated with organ injury and systemic inflammation that is attenuated by dexamethasone.
Nin N, Peñuelas O, de Paula M, Lorente JA, Fernández-Segoviano P, Esteban A.
Crit Care Med
. 2006 Apr;34(4):1093-8.

 

2005

[Frequency of diagnosis and clinic presentation of glomerulopathies in Uruguay].
Mazzuchi N, Acosta N, Caorsi H, Schwedt E, Di Martino LA, Mautone M, Gadola L, Petraglia A, Noboa O; Programa de Prevención y Tratamiento de las Glomerulopatías.
Nefrologia
. 2005;25(2):113-20.

[Frequency of diagnosis and clinic presentation of glomerulopathies in Uruguay].
Mazzuchi N, Acosta N, Caorsi H, Schwedt E, Di Martino LA, Mautone M, Gadola L, Petraglia A, Noboa O; Programa de Prevención y Tratamiento de las Glomerulopatías.
Nefrologia
. 2005;25(2):113-20.

Pulmonary artery smooth muscle activation attenuates arterial dysfunction during acute pulmonary hypertension.
Santana DB, Barra JG, Grignola JC, Ginés FF, Armentano RL.
J Appl Physiol
. 2005 Feb;98(2):605-13.

Large tidal volume mechanical ventilation induces vascular dysfunction in rats.
Nin N, Valero JA, Lorente JA, de Paula M, Fernández-Segoviano P, Sánchez-Ferrer A, Esteban A.
J Trauma
. 2005 Sep;59(3):711-6.

Hypocapnic but not metabolic alkalosis impairs alveolar fluid reabsorption.
Myrianthefs PM, Briva A, Lecuona E, Dumasius V, Rutschman DH, Ridge KM, Baltopoulos GJ, Sznajder JI.
Am J Respir Crit Care Med
. 2005 Jun 1;171(11):1267-71.

Gene transfer of the Na+,K+-ATPase beta1 subunit using electroporation increases lung liquid clearance.
Machado-Aranda D, Adir Y, Young JL, Briva A, Budinger GR, Yeldandi AV, Sznajder JI, Dean DA.
Am J Respir Crit Care Med
. 2005 Feb 1;171(3):204-11.

 

2004

Septic diaphragmatic dysfunction is prevented by Mn(III)porphyrin therapy and inducible nitric oxide synthase inhibition.
Nin N
, Cassina A, Boggia J, Alfonso E, Botti H, Peluffo G, Trostchansky A, Batthyány C, Radi R, Rubbo H, Hurtado FJ.
Intensive Care Med
. 2004 Dec;30(12):2271-8.

Epidemiology of acute lung injury and acute respiratory distress syndrome.
Frutos-Vivar F, Nin N, Esteban A.
Curr Opin Crit Care. 2004 Feb;10(1):1-6. Review.

Gadola L, Noboa O, Márquez MN, Rodriguez MJ, Nin N, Boggia J, Ferreiro A, García S, Ortega V, Musto ML, Ponte P, Sesser P, Pizarrosa C, Ravaglio S, Vallega A.
Kidney Int. 2004 Apr;65(4):1224-30.

Leukotriene D4 activates alveolar epithelial Na,K-ATPase and increases alveolar fluid clearance.
Sloniewsky DE, Ridge KM, Adir Y, Fries FP, Briva A, Sznajder JI, Sporn PH.
Am J Respir Crit Care Med
. 2004 Feb 1;169(3):407-12.

 

2003

[The vascular smooth muscle of great arteries: local control site of arterial buffering function?].
Bia D, Armentano RL, Grignola JC, Craiem D, Zócalo YA, Ginés FF, Levenson J.
Rev Esp Cardiol
. 2003 Dec;56(12):1202-9.

[Acute pulmonary hypertension: protective role of vascular smooth muscle activation].
Grignola JC
, Bia D, Ginés F, Armentano RL.
Rev Esp Cardiol
. 2003 Nov;56(11):1077-84.

Improved pulmonary artery buffering function during phenylephrine-induced pulmonary hypertension.
Mol Cell Biochem. 2003 Apr;246(1-2):19-24.
Bia D, Grignola JC, Armentano RL, Ginés FF.

 

2002

Angiotensin II stimulation of renal epithelial cell Na/HCO3 cotransport activity: a central role for Src family kinase/classic MAPK pathway coupling.
J Membr Biol. 2002 May 15;187(2):135-45.
Robey RB, Ruiz OS, Espiritu DJ, Ibañez VC, Kear FT, Noboa OA, Bernardo AA, Arruda JA.

Regulation of mesangial cell hexokinase activity and expression by heparin-binding epidermal growth factor-like growth factor: epidermal growth factors and phorbol esters increase glucose metabolism via a common mechanism involving classic mitogen-activated protein kinase pathway activation and induction of hexokinase II expression.
Robey RB, Ma J, Santos AV, Noboa OA, Coy PE, Bryson JM.
J Biol Chem
. 2002 Apr 26;277(17):14370-8.

Do CLL B cells correspond to naive or memory B-lymphocytes? Evidence for an active Ig switch unrelated to phenotype expression and Ig mutational pattern in B-CLL cells.
Leukemia. 2002 Dec;16(12):2438-46.
Oppezzo P, Magnac C, Bianchi S, Vuillier F, Tiscornia A, Dumas G, Payelle-Brogard B, Ajchenbaum-Cymbalista F, Dighiero G, Pritsch O.

 

2001

Diverticular disease and treatment with gastric acid inhibitors do not predispose to peritonitis of enteric origin in peritoneal dialysis patients.
Perit Dial Int. 2001 Jul-Aug;21(4):360-4.
del Peso G, Bajo MA, Gadola L, Millán I, Codoceo R, Celadilla O, Castro MJ, Aguilera A, Gil F, Selgas R.

[Synchronization of the contraction of the right ventricle against an acute afterload increase. Left ventricle-like mechanical function of the right ventricle].
Ginés F, Grignola JC.
Rev Esp Cardiol
. 2001 Aug;54(8):973-80.

 

2000

Effects of halothane on respiratory mechanics and lung histopathology in normal rats.
Br J Anaesth. 2000 Mar;84(3):372-7.
Reta GS, Riva JA, Piriz H
, Medeiros AS, Rocco PR, Zin WA.

 

1999

[Study of the relaxation phase of the right ventricle].
Grignola JC
, Pontet J, Vallarino M, Ginés F.
Arch Inst Cardiol Mex
. 1999 Jan-Feb;69(1):12-6.

[The characteristics proper of the cardiac cycle phases of the right ventricle].
Grignola JC
, Pontet J, Vallarino M, Ginés F.
Rev Esp Cardiol
. 1999 Jan;52(1):37-42.

 

Selected Topics in Chronic Lymphocytic Leukemia Pathogenesis

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